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Because of the risk of serious side effects with long-term use, treatment of rheumatic disease with corticosteroids is controversial. They should generally be reserved for patients in whom other anti-inflammatory drugs are unsuccessful or until other drugs take effect (see DMARDs below).
The principal organ of excretion for the majority of drugs is the kidney. The physiological functioning of this organ declines with age. At rate is approximately half that at age via the kidney are liable to accumulate in older patients.
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