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Resistance is a major problem with macrolides, due to reduced uptake into bacterial cells and alteration of macrolide binding proteins.
Raynauds disease can occur on its own, or as a consequence of systemic sclerosis or systemic lupus erythematosus, both chronic inflammatory diseases. Adverse effects of class II calcium channel blockers are reflex tachycardia, headache, flushing, palpitations and ankle oedema.
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Treatments are often painful and lengthy with poor results. Warts have a very good blood supply and this may be why they are able to withstand prolonged treatment with topical keratolytics.