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If potassium ion concentration is reduced, the inhibitory effects of digoxin are increased. Diuretics may also increase plasma lipid levels and cause glucose intolerance and insulin resistance, so they have to be used with caution in individuals with hyperlipidaemia andor diabetes. In addition, most diuretics produce an increase in plasma uric acid levels, which may lead to gout.
ACE inhibitors are used to treat cardiac failure and hypertension. Inhibition of ACE prevents formation of angiotensin II, which is a powerful vasoconstrictor (see Figure resistance and therefore reduction in blood pressure. Reduction in blood pressure also improves cardiac output.
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How can you reassure her that this will not happen again. You should be able to answer these review questions from the material in this chapter. injection of drugs. and active transport of drug molecules across cell membranes. the gastrointestinal tract, its distribution around the body and its excretion by the kidneys. on drug excretion.
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Prolonged use of anti-inflammatory corticosteroids can also impair the function of fibroblasts, which reduces the ability of wounds to heal. In addition, changes in the synthesis of collagen occur resulting in thinning and loss of the mechanical resistance in the skin.
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They should not be taken at the same time as milk because it impairs their absorption.
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Many are due to drug allergy, but there are other causes.
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Nephrotoxicity is a risk with frequent administration of contrast agents.
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The common conditions predisposing to high risk of renal toxicity with contrast agents are listed below: Pre-existing renal failure Serum creatinine above Hypovolaemia Ventricular dysfunction Hypertension Dehydration Nephrotoxic drugs Diabetes mellitus with renal impairment Advanced age Multiple myeloma Any patient requiring high dose Toxicity is also related to chemical composition of a contrast agent.
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Drugs that either improve the blood supply to the myocardium, or reduce its metabolic demand for oxygen or both can be used to treat angina.
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Hypokinesia and rigidity are both reduced but tremor is not. Overall, there is improvement in facial expression, manual dexterity, gait and speech.
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