Benzodiazepines enhance the effects of GABA at its receptor, but they do not bring about the opening of chloride ion channels in the absence of GABA. Because of the existence of benzodiazepine receptors, it seems likely that there must be either an endogenous benzodiazepine or an endogenous anxiolytic substance, although none has been conclusively identified yet. For treatment of anxiety, benzodiazepines such as diazepam and oxazepam are used because they have a slower onset of action with a longer duration than others.
Benzodiazepine anxiolytics have been prescribed to almost anyone with stress-related symptoms, unhappiness or minor physical trauma. This kind of use is now considered unsuitable.
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Treatment should begin one or two weeks before travelling to areas where malaria is endemic and be continued for at least four weeks after returning. No form of malaria prophylaxis is completely effective and other precautions should be taken.
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PUp until quite often, he has been looking after himself very well.
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Larger doses depress respiration and lower the level of consciousness of the patient.
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PLidocaine should not be treated in patients with hypovolaemia, as this would make in higher plasma levels and intravenous increase in risk of radiotherapy effects, or in bradycardia, because there may be further slowing of the effect.
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PApart from their local anaesthetic action, local anaesthetics have anticholinergic activity.
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