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Loperamide is an opiate drug that decreases motility of the intestine. It does not cross the bloodbrain barrier easily and therefore does not have the central nervous system effects of other opiates.

  • Examples of vinca alkaloids are vinblastine, vincristine and vindesine.
  • There are two main groups of oral hypoglycaemics: the sulfonylureas and the biguanides.
  • After this the cycle repeats itself.
  • Nutritional rickets results from inadequate exposure to sunlight or deficiency of vitamin D.
  • Both these actions result in raised levels of monoamines at the synapse.
  • Polyunsaturated fats are said to encourage cholesterol loss in faeces and its conversion to bile acids.
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Merkel cells are attached to a sensory neuron and function to detect the sensation of touch. Melanocytes produce the pigment melanin, which contributes to skin colour and provides some protection against sunlight.


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Individuals have different reactions to different NSAIDs. Some tolerate a particular drug while others do not. In the treatment of chronic pain, a number of drugs may be tried until one is found that produces the most acceptable result to the patient. Aspirin, is often the first choice of analgesia for mild to moderate pain in adults. In large doses, aspirin has anti-inflammatory effects and has a role in the treatment of chronic inflammatory disease.

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Central side effects with long-term therapy of levodopa can be serious enough for treatment to be stopped. These include dyskinesias, restlessness, anxiety, confusion, disorientation, insomnia or a schizophrenia-like syndrome. Dyskinesias can be particularly severe, involving unusual writhing movements of the limbs and grimacing and chewing movements of the face. After five years of treatment about half of patients will experience the drug becoming less effective and a gradual recurrence of symptoms, especially hypokinesia, occurs. Another type of deterioration is the shortening of action of each dose with time (end of dose deterioration) and unpredictable fluctuations in response to treatment, which can happen quite abruptly.

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Sulfasalazine is split by bacteria in the colon to produce aminosalicylic acid and sulfapyridine, the latter of which is probably the active drug.

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