Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches. A governmentally-recognized ID which uniquely identifies the product within its regulatory market. A combination sumatriptan and naproxen tablet is indicated for the treatment of migraines with or without auras in patients 12 years of age and older. Sumatriptan constricts cranial blood vessels and prevents the release of vasoactive peptides. Comprehensive structured data on known drug adverse effects with statistical prevalence.
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Do not use this medicine for a headache that is different from your usual migraines. Talk to your doctor about what to do for regular headaches. To relieve your migraine as soon as possible, use this medicine as soon as the headache pain begins. Even if you get warning signals of a coming migraine an aura, you should wait until the headache pain starts before using sumatriptan. Ask your doctor ahead of time about any other medicine you might take if sumatriptan does not work. After you use the other medicine, check with your doctor as soon as possible. Headaches that are not relieved by sumatriptan are sometimes caused by conditions that need other treatment.
Serotonin-receptor 1B and 1D agonist triptan Used for acute treatment of migraine with or without aura and cluster headaches Potential for serious cardiac adverse effects. May repeat dose once with a minimum 1-hour interval between doses if migraine symptoms return. The maximum dose within 24 to 48 hours is 12 mg. If side effects are limiting, a lower dose may be used. The maximum cumulative daily dose is 12 mg. May repeat a dose 2 hours after the first dose if imitrex 25 mg headache has not resolved or returns after transient improvement.
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Sumatriptan should be used only in patients in whom a clear diagnosis of migraine or cluster headache has been established. The manufacturers and some clinicians state that the drug is not to be used for the management of hemiplegic or basilar migraine or for prophylaxis of migraine or cluster headache. In patients with a history of migraine or cluster headache who present with atypical symptoms e. See Cautions: Precautions and Contraindications. Drug therapy in the management of migraine headache must be individualized and adjusted based on the severity and frequency of attacks, response to therapy single or multiple drugs, and tolerance to drug-induced adverse effects.
White to off — white, capsule shaped, biconvex, uncoated tablets, debossed with 'C' on one side and '33' on the other side. Sumatriptan is recommended as monotherapy for the acute treatment of a migraine attack and should not be given concomitantly with ergotamine or derivatives of ergotamine including methysergide see section 4. It is advisable that sumatriptan be given as early as possible after the onset of a migraine headache. It is equally effective at whatever stage of the attack it is administered. The recommended dose of oral sumatriptan is a single 50 mg tablet. Some patients may require mg.
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Common side effects include chest pressure, feeling tired, feeling of the world spinning, vomiting, tingling. Sumatriptan was patented in and approved for medical use in Sumatriptan is effective for ending or relieving the intensity of migraine and cluster headaches. Overdose of sumatriptan can cause sulfhemoglobinemia, a rare condition in which the blood changes from red to green, due to the integration of sulfur into the hemoglobin molecule. CGRP is believed to cause sensitization of trigeminal nociceptive neurons, contributing to the pain experienced in migraine.
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USES: Sumatriptan is used to treat migraines. Overuse of drugs to treat sudden migraine attacks can sometimes lead to worsening of headache medication overuse headache or rebound headache.
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Imitrex sumatriptan is a headache medicine that narrows blood vessels around the brain.
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Doses of 50 mg and mg may provide a greater effect than the mg dose, but doses of mg may not provide a greater effect than the mg dose.
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It is used to treat migraine headaches with or without aura warning signs that occur prior to the onset of a migraine.
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That sumatriptan tablets are effective and well tolerated in the acute treatment of migraine has been established, but the relationship between dose and efficacy has not been adequately defined to date in clinical trials.
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Five years have elapsed since the advent of triptan options as the treatment of choice for migraine.
Serotonin syndrome may occur, particularly during combined use with SSRIs eg, fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, escitalopram or SNRIs eg, venlafaxine, duloxetine ; discontinue therapy if it occurs. Data from a prospective pregnancy exposure registry and epidemiological studies of pregnant women have not detected increased frequency of birth defects or consistent pattern of birth defects among women exposed to sumatriptan compared with general population; in developmental toxicity studies in rats and rabbits, oral administration of sumatriptan to pregnant animals was associated with embryolethality, fetal abnormalities, and pup mortality; when administered by intravenous route to pregnant rabbits, sumatriptan was embryolethal.
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Your medication may look different. If you have questions, ask your pharmacist.
Once absorbed, distribution of the drug to different parts of the body follows. This necessarily includes passage through the liver. Most drugs are treated as potentially toxic substances and are metabolized by the liver. This detoxifies them and some drugs are almost totally inactivated on first pass through the liver. Eventually a drug will be excreted from the body. This usually occurs via the kidneys, although some drugs can be lost in faeces or exhaled air.
It is here that complex aspects of behaviour such as memory, thought and language reside. Within the nervous system neurons make connections with each other called synapses. At the synapse, the neurons do not touch each other but are separated imitrex 25 mg a microscopic gap, the synaptic cleft. When a nerve impulse arrives at a synapse, chemical substances are released. These are neurotransmitters, which are stored in pre-synaptic vesicles. On release they cross the synaptic cleft and bind to receptors on the post-synaptic neuron.