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This results in irreversible inhibition of viral polymerase. (Note: a nucleoside is a base [either purine or pyrimidine] plus a sugar molecule; a nucleotide is a base plus a phosphorylated sugar molecule.
Many anti-psychotic drugs have what are called Parkinsonian or extra-pyramidal side effects. These are abnormalities of movement that resemble Parkinsons disease (see page Anti-psychotics that also have anti-cholinergic activity cause fewer Parkinsonian side effects. A more serious and irreversible side effect related to Parkinsonism is tardive dyskinesia.
This occurs after many years of anti-psychotic drug use and is characterized by abnormal and disabling involuntary movements of the face, tongue, trunk and limbs. Phenothiazines have pronounced sedative effects.
Cancer is a chronic condition and it is highly feasible to set up a CMP between the independent prescriber and supplementary prescriber (therapy radiographer). In many respects, supplementary prescribing is better than PGDs and the values of this mechanism with respect to toxicity management are indicated below: PGDs are inflexible, being restricted to specific medicines at specific doses.
Doses cannot be altered and medication cannot be changed to an alternative medicine (within a specific PGD); PGDs require regular updating in accordance with Trust policies, and the associated processes can be labour intensive; supplementary prescribing allows therapy radiographers to have broad professional latitude within their competence in the medicines they prescribe and the amount they administer.
This allows for more responsive and individualized care and management. Notwithstanding the above, therapy radiographers have yet to fully realize the importance of supplementary prescribing in their practice and until this is incorporated and evaluated it is likely that widespread uptake will be limited.