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Olanzapine, an atypical antipsychotic agent, is not commonly associated with significant hyperprolactinemia due to its weak dopamine binding capacity. A year-old married female presented with a history suggestive of OCD for last 20 years. She was treated with a number of antiobsessive drugs in adequate doses and for adequate duration but with minimal response. Her past and family histories were not significant. Personal history revealed interpersonal problems with husband and her in-laws. The patient was started on a combination of clomipramine and sertraline. The compliance was adequately ensured and the combination was continued for 4 months at the same dosage. The patient, however, did not cooperate for behavior therapy as, at times, there was no co-therapist available, and on other occasions, the patient did not comply with the instructions given. The enlargement was diffuse, symmetrical, non tender without galactorrhea. She also had amenorrhea for 2 months.
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