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Inert ingredients for the tablets are: dibasic calcium phosphate; magnesium stearate; polyethylene glycol; starch; sucrose. The 25 mg tablets also contain: Yellow 6 Lake; Yellow 10 Lake. For the treatment of vertigo associated with diseases affecting the vestibular system, the recommended dose is 25 to mg daily, in divided dosage, depending upon clinical response. There may be increased CNS depression when meclizine is administered concurrently with other CNS depressants, including alcohol, tranquilizers, and sedatives. Based on in-vitro evaluation, meclizine is metabolized by CYP2D6.

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Although scopolamine generally is considered to be the most effective drug for the treatment of motion sickness, most clinicians prefer an antihistamine such as meclizine because it produces fewer adverse anticholinergic effects than does scopolamine. Meclizine and dimenhydrinate generally are considered to be equally effective in the treatment of motion sickness, but dimenhydrinate causes drowsiness more frequently. Meclizine has a longer duration of action than scopolamine and most other antihistamines. Promethazine may be more effective than other antihistamines in the treatment of motion sickness. Meclizine has been used in the symptomatic treatment of vertigo associated with diseases affecting the vestibular system e. Although meclizine is a histamine H 1 -receptor antagonist, its use in allergic states has not been evaluated.

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Air enters the nose through two openings, the nostrils. The nasal passages are lined with a moist hairy mucous membrane that traps dust, dirt and bacteria breathed in with air. As air passes through the nasal passages it is also warmed and moistened. The epiglottis is a flap of cartilage that closes the trachea during swallowing. The larynx is situated in the pharynx at the top of the trachea.