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Drug: Nimodipine Nimodipine 30 mg 3 times a day tid. Drug: Placebo Matching placebo three times a day tid.
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Both of these effects are due to the inhibition of an enzyme, cyclo-oxygenase. This enzyme normally converts arachidonic acid to prostaglandins, thromboxanes and prostacyclin. Arachidonic acid is an unsaturated long chain fatty acid found in all cell membranes, which is released as a result of tissue damage. Prostaglandins play a role in inflammation by causing vasodilation and increased vascular permeability and in pain by sensitizing sensory nerve endings to the effects of other mediators such as bradykinin.
Thromboxanes promote platelet aggregation. Prostacyclin is produced from arachidonic acid in undamaged endothelium of blood vessels and plays a role in preventing unnecessary blood clotting.
Because of the anti-inflammatory effects they are known as non-steroidal anti-inflammatory drugs, or NSAIDs ( Figure NSAIDs exert their effects by inhibition of the enzyme cyclo-oxygenase. This results in cheap reminyl 8 production of prostaglandins and thromboxanes because COX normally catalyses their formation from arachidonic acid. Prostaglandins play a role in pain by sensitising sensory nerve endings to the effects of other mediators such as bradykinin.
Thromboxanes promote platelet aggregation. There are many different drugs of this type, none of which is a more potent analgesic than aspirin.