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What is spironolactone, and how does it work mechanism of action? Aldactone spironolactone is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It also can be used in combination with other drugs to treat diuretic-induced low potassium hypokalemia and high blood pressure. Aldactone also is used to counteract the effects of excessive adrenal aldosterone production hyperaldosteronism that can occur from a tumor in the adrenal gland or enlarged adrenal glands hyperplasia of the adrenal glands. It may be given alone or with other diuretic agents that act more proximally in the renal tubule. What are the uses for spironolactone?

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Therefore the only time we can supply an increased quantity of a prescribed medicine is if the doctor prescribes that quantity for you. This prior approval to prescribe grants the doctor the Authority to prescribe the desired medicine and have it funded under the PBS. Pharmacists cannot dispense the item as a pharmaceutical benefit unless it has been approved by Medicare Australia indicated by the presence of the approval number. The pharmacist will determine if this product is appropriate for you and if so, approve the order. Leaves warehouse in business days. Temporarily suspended until further notice. We apologise for any inconvenience.

Spironolactone is a potassium-sparing diuretic. The drug may also be used in combination with other medications to treat precocious early puberty and myasthenia gravis, a neuromuscular disease. Though spironolactone has been around for over 25 years, the FDA is still updating the drug's safety labeling. The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess. Because of its anti-androgen activity, spironolactone is also used off-label to treat female-pattern hair loss and hirsutism.

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Aldactone spironolactone is a potassium-sparing diuretic water pill that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. Aldactone is used to treat heart failure, high blood pressure hypertension, or hypokalemia low potassium levels in the blood. Aldactone is also used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body. You should use Aldactone with caution if you have kidney problems, high levels of potassium in your blood, Addison's disease, if you are unable to urinate, or if you are also taking eplerenone.

Long-term maintenance therapy for patients with discrete aldosterone-producing adrenal adenomas who are not candidates for surgery or for patients with bilateral micro or macronodular adrenal hyperplasia idiopathic hyperaldosteronism. May be used as long-term maintenance therapy at the lowest effective for patients who are considered unsuitable for surgery. Management of edema in patients with cirrhosis of the liver when edema are unresponsive to fluid and sodium restriction or nephrotic syndrome when treatment of the underlying disease, fluid restriction and sodium intake, and the use of other diuretics produce an inadequate response. Substantially excreted by the kidney, and risk of adverse reactions to this drug may be greater in patients with impaired renal function; monitor renal function. Hyperkalemia may occur; monitor serum potassium within 1 week of initiation or titration of spironolactone and regularly thereafter; if hyperkalemia occurs, reduce dose or discontinue treatment and treat hyperkalemia. Excessive diuresis may cause symptomatic dehydration, hypotension and worsening renal function, particularly in salt-depleted patients or those taking angiotensin converting enzyme ACE inhibitors and angiotensin II receptor blockers ARBs.

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Spironolactone is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. Label Off label uses of spironolactone involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris. Spironolactone was developed in, marketed in, and approved by the FDA on January 21, A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Spironolactone has antiandrogenic activity which leads to many of its off label uses.

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ALDACTONE is indicated as add-on therapy for the treatment of hypertension, to lower blood pressure in patients who are not adequately controlled on other agents. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals.

However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Do not use more of this product, or more often, than prescribed. It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. This medication is more effective if taken with food. Always take it with a meal or a snack.