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They may be formulated in this way because the active drug is difficult to administer, whereas the inactive prodrug does not cause the same complications, or because the active drug is not absorbed or distributed to its intended site of action easily. Most tissues in the body have the enzymes capable of metabolizing a variety of substances. However, as one of the main functions of the liver is the metabolism of toxic substances produced during normal metabolic processes, it is not surprising that the majority of drug metabolism takes place in the liver.
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Be careful not to become dehydrated during hot weather while taking oxybutynin as heat stroke can occur.
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Dose should be decreased in patients with moderate hepatic impairment; not recommended for use in patients with severe hepatic impairment.
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