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The cardiovascular, respiratory, endocrine, musculoskeletal, skin and central nervous systems are considered. An outline of normal physiology of the systems is included where appropriate and relevant diseases described briefly. This is not intended to be a physiology book or a pathophysiology book. Should the reader need to consult such books, suggestions are given in the bibliography. Major groups of drugs are discussed, with emphasis on areas of relevance to the three professions for whom the book is intended.

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The three ways by which substances, including drugs, can cross cell membranes are simple diffusion, facilitated diffusion and active transport. Diffusion is the mechanism by which the vast majority of drugs pass across cell membranes. Both simple diffusion and facilitated diffusion are passive processes in that no energy is required other than the kinetic energy of the molecules themselves. Several factors are known to influence the diffusion of substances across the cell membrane: the membrane must be permeable to the substance in question; there must be a concentration gradient; the molecular sizeweight of the substance must be small enough; a large surface area is necessary for efficient diffusion; a short distance is necessary for efficient diffusion. In practice, there is a concentration gradient because the drug is given in sufficient dose, most drug molecules are small enough to be absorbed (otherwise, they would be of no use) and the surface area and distance of the absorbing membrane are favourable.

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