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Characteristics of cancer include uncontrolled cell division with excessive growth of undifferentiated cells. Cancer cells invade surrounding tissues, whereas normal cells do not survive outside their normal boundaries. Cancer cells may travel to distant sites in the body via the blood and lymph to form secondary tumours that are called metastases. As cells repeatedly divide a mass forms known as a tumour, which needs a blood supply. Angiogenesis is the process by which tumours develop their own blood supply.


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Diuretics are used to treat cardiac failure and hypertension. Because cardiac failure results in hypertension and leads to oedema, diuretics are used in both cases because they encourage water loss and therefore produce a reduction in circulating blood volume. This lowers blood pressure, reduces the work the heart has to do and improves oedema by encouraging the movement of fluid from the tissues into the circulation. Of the different types of diuretics, the ones used in cardiac failure and hypertension are thiazide diuretics and loop diuretics. Thiazide diuretics work by inhibiting sodium and chloride ion transport in the distal convoluted tubule of the kidney and therefore limit water reabsorption.


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Authored by Dr. Gary Lee Crump, MD

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