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The frequency of contrast agent injection and dose are known risk factors for renal toxicity. Ideally, in patients at high risk of renal toxicity, there should be five days between administrations and the lowest possible dose of either non-ionic monomer or non-ionic dimer should be used. Adverse reactions include the risk of acute renal failure due to blockage of tubules because contrast agents are relatively insoluble. Adequate water intake by the patient is essential to reduce the risk of renal toxicity.
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