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Do not use on broken or infected skin. Before you start to use it You must tell your doctor or pharmacist if: You are allergic to any other medicines, foods, dyes or preservatives. You have any of these medical conditions, or have had them in the past: stomach ulcers bleeding from the bowel or stomach asthma kidney, liver or heart problems raised blood pressure swelling with fluid oedema bleeding problems inflammation of the intestines such as Crohn's disease. NSAIDs have been associated with reversible infertility in some women.

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Silymarin, as well as adjunct use of silymarin with piroxicam, significantly reduced serum levels of IL—alpha1, IL—8, and the complement proteins C3 and C4 after 8 weeks compared with the pretreatment levels. Piroxicam significantly reduced IL—8 compared with pretreatment, while no reductions were seen with meloxicam or for its adjunct use with silymarin.

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