Depakote is a medication known as an anticonvulsant that is used to treat the manic symptoms of bipolar disorder. It is also used to treat seizures and prevent migraine headaches. Depakote was first approved by the FDA in
Divalproex sodium can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by certain genetic disorders. You should not use divalproex sodium if you have liver disease, a urea cycle disorder, or a genetic disorder such as Alpers' disease or Alpers-Huttenlocher syndrome. Divalproex sodium may harm an unborn baby, but minipress prazosin 5 mg a seizure during pregnancy could harm both mother and baby. The benefit of preventing seizures may outweigh any risks to the baby. Do not use divalproex sodium to prevent migraine headaches if you are pregnant.
Or in a crisis, text NAMI to Note: Throughout this fact sheet, the medication will be referred to as valproate. All FDA black box warnings are at the end of this fact sheet.
Depakote Delayed-Release Tablets are indicated for treatment of manic episodes associated with bipolar disorder. Depakote ER is indicated for acute treatment of manic or mixed episodes associated with bipolar disorder, with or without psychotic features. A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood. The effectiveness of valproate for long-term use in mania, i.
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This medicinal product is subject to additional monitoring. It is also known as divalproex sodium USAN. Treatment of manic episode in bipolar disorder when lithium is contraindicated or not tolerated.
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Monitor motor and cognitive functions routinely. Elderly monitor fluid and nutritional intake, and for somnolence. Advise females of childbearing potential of risks to fetus. Nursing mothers: monitor infants. Potentiates carbamazepine, ethosuximide, lamotrigine, phenobarbital, phenytoin, tolbutamide, warfarin, zidovudine, amitriptyline, nortriptyline, propofol, rufinamide. Potentiated by aspirin, felbamate. Efficacy reduced by rifampin, phenytoin, carbamazepine, phenobarbital, carbapenems, estrogen-containing hormonal contraceptives; monitor serum valproate concentrations.
may induce absence status in patients with history of absence seizures. Concomitant topiramate may cause hyperammonemic encephalopathy, hypothermia. May interfere with urine ketone and thyroid tests. Others: see full labeling. Increased risk of hepatotoxicity in patients with congenital metabolic disorders, multiple AEDs, severe seizure disorders with mental retardation, organic brain disorders, mitochondrial disorders, esp.
Advise females of childbearing potential of risks to fetus; if treatment needed, use effective contraception. Monotherapy or adjunct in complex partial seizures; simple or complex absence seizures. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially Take this medicine exactly as directed by your doctor.
Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To keep blood levels constant, take this medicine at the same time each day and do not miss any doses. Ask your doctor if you have any questions. Swallow the sprinkle capsules whole. Swallow the extended-release tablet or tablet whole with a full glass of water. Do not split, crush, or chew it.
Part of the medicine may pass into your stool after your body has absorbed the medicine. Check with your doctor right away if this happens. The dose of this medicine will be different for different patients. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
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Divalproex sodium is used to treat certain types of seizures epilepsy. This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Divalproex sodium is also used to treat the manic phase of bipolar disorder manic-depressive illness and helps depakote er 250 mg migraine headaches.
Depakote ER is used to help treat convulsions. Not valid at any other pharmacy. Walmart cards must be used at Walmart pharmacies. Prices for some drugs may be higher or vary in some states including, but not necessarily limited to, CA and MN.
General Population: Hepatic failure resulting in fatalities has occurred in patients receiving valproate and its derivatives. When Depakote ER is used in this patient group, it should be used with extreme caution and as a sole agent. Alpers Huttenlocher Syndrome. This older group of patients should be closely monitored during treatment with Depakote ER for the development of acute liver injury with regular clinical assessments and serum liver testing.