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For example some PGDs have indicated that the amount of Omnipaque (an X-ray contrast agent) to be administered can exceed that outlined on the product information sheet. The only evidence used to support this is that some peers do this in other Trusts. Not only does this practice fall short of minimizing risk but it might also fail one component of the Bolam test (Bolam v Friern Hospital Management Committee, City and Hackney Health Authority, In some departments, it is clear that the implementation and development of prescription, supply and administration of medicines by radiographers has occurred in isolationsemi-isolation to the Trust as a whole.
Consequently, good practice that is regarded as quite basic to other health professions has been overlooked and not implemented.

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Because of the risk of retinopathy, long-term therapy should be reserved for cases in which all other DMARDs have failed.
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Plasma protein concentration also falls with age. This means that for extensively protein bound drugs there will be a greater concentration of free drug than expected. This could lead to increased incidence of side effects. This is the case with pethidine (an analgesic).
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On cessation of corticosteroid use, the structure of the skin may recover to a degree but there may be permanent damage in the form of striae particularly at sites of fat accumulation or oedema.
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