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The lungs are adapted for absorption of oxygen having a large surface area for diffusion and a good blood supply. Particle size is a major determinant of absorption from this site of administration.
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General use of antibiotics and their mechanisms of action and adverse reactions are discussed in Chapter Pneumonia is inflammation of the lower parts of the lungs with accumulation of fluid in or around the alveoli.
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The epiglottis is a flap of cartilage that closes the trachea during swallowing.
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This is especially important for new drugs as adverse reactions can be missed during clinical trials.
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Common adverse effects of oral griseofulvin are diarrhoea, nausea, vomiting, headache and photosensitivity.
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Drugs to treat different stages in the life cycle of the malaria parasite are available.
Cautious use of contrast agents is indicated in patients with epilepsy, hepato-renal syndrome, severe respiratory disease and diabetes. They should not be administered to patients who are taking metformin for Type agents can increase the risk of lactic acidosis.
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Hypersecretion of aldosterone (Conns syndrome) is treated with an aldosterone antagonist. Hypersecretion of cortisol (Cushings syndrome) and testosterone are managed with surgery or irradiation.
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Flecainide is an alternative to lidocaine for the treatment of ventricular arrhythmia and can be used orally for disabling paroxysmal atrial fibrillation. Adverse effects of flecainide are nausea, vomiting and precipitation of arrythmias. Quinidine can suppress all types of arrhythmia, but also cause them. Because of this, it is rarely used without specialist guidance.
Adverse effects of quinidine are nausea, vomiting, diarrhoea, blurred vision, cardiac depression and arrhythmia. Amiodarone is used to treat arrhythmia.
Mr Davies says he has not been feeling quite right lately and wonders if it could be the new drug. Mr Davies current medication is as follows: Lithium carbonate, Sodium valproate, Atenolol, Amlodipine Lisinopril, Chlorpromazine, Discuss this patient using the questions as a guide. Identify which of Mr Davies drugs are for hypertension and which are for bipolar disorder. Consider if there are likely to be any interactions between the many drugs that Mr Davies is taking.
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