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This is thought to occur through inhibition of the NaK ATPase pump in the cardiac cell membrane, which results in more calcium ions being available for contraction. This is because normally calcium ions are exchanged for sodium ions across the cardiac muscle cell membrane at the end of a contraction and thereby removed from the cell. If the NaK ATPase pump is inhibited, the concentration of sodium ions in the cell increases reducing the concentration gradient for exchange with calcium ions.
Thus, the concentration of calcium ions within the cell rises. The effect of increased intracellular calcium ion levels is a more controlled forceful contraction of the myocardium.

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Some imidazoles enhance the anticoagulant properties of warfarin. Adverse effects with topical preparations are irritation and itching of the skin.